Recent advances in organocatalytic asymmetric aza-Michael reactions of amines and amides

• Pratibha Sharma,
• Raakhi Gupta and
• Raj K. Bansal

Beilstein J. Org. Chem. 2021, 17, 2585–2610, doi:10.3762/bjoc.17.173

• asymmetric aza-Michael reaction (aza-MR) alone or in tandem with other organic reaction(s) is an important synthetic tool to form new C–N bond(s) leading to developing new libraries of diverse types of bioactive nitrogen compounds. The synthesis and application of a variety of organocatalysts for

• organocatalysts in asymmetric aza-MR. Keywords: asymmetric aza-Michael reaction; covalent bonding catalysis; nitrogen heterocycles; non-covalent bonding catalysis; organocatalysis; Introduction The Michael reaction though discovered about 135 years ago [1][2] continues to attract attention of the chemists owing

• additions of these heteroarenes with crotonaldehyde yielded the adducts in moderate to good enantioselectivity under dual catalysis of chiral amines (Scheme 5) [69]. Conclusion The asymmetric aza-Michael reaction being a useful synthetic strategy for constructing C–N bonds to make a variety of nitrogen